Activation of the aryl hydrocarbon receptor inhibits neuropilin-1 upregulation on IL-2-responding CD4+ T cells

Neuropilin-1 (Nrp1), a transmembrane protein expressed on CD4+ T cells, is mostly studied in the context of regulatory T cell (Treg) function. More recently, there is increasing evidence that Nrp1 is also highly expressed on activated effector T cells and that increases in these Nrp1-expressing CD4+...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Simone Sandoval, Keegan Malany, Krista Thongphanh, Clarisa A. Martinez, Michael L. Goodson, Felipe Da Costa Souza, Lo-Wei Lin, Nicolle Sweeney, Jamie Pennington, Pamela J. Lein, Nancy I. Kerkvliet, Allison K. Ehrlich
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-11-01
Subjects:	aryl hydrocarbon receptor neuropilin-1 CD4+ T cells IL-2 immunomodulators
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1193535/full