UPLC-MS/MS method for simultaneous determination of pyrantel, praziquantel, febantel, fenbendazole and oxfendazole in dog plasma and its application to a bioequivalence study

A rapid, sensitive and reliable ultra–performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) was developed and validated for the simultaneous quantitation of pyrantel (PYR), praziquantel (PRA), febantel (FBT) and its active metabolites, fenbendazole (FEN) and oxfendazole (OXF) in do...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Fengyichi Zhang, Fanxi Guo, Xinyu Zhao, Chongyang Li, Junli Wang, Mengyun Wang, Ruixia Ma, Baochang Chen, Qiangqiang Miao, Yimeng Wang, Zihan Wang, Di Cao, Zugong Yu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Subjects:	pyrantel praziquantel febantel fenbendazole oxfendazole UPLC-MS/MS
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1544215/full