Genetic reinstatement of RIG-I in chickens reveals insights into avian immune evolution and influenza interaction

Retinoic acid-inducible gene I (RIG-I) activates mitochondrial antiviral signaling proteins, initiating the antiviral response. RIG-I and RNF135, a ubiquitin ligase regulator, are missing in domestic chickens but conserved in mallard ducks. The chickens’ RIG-I loss was long believed to be linked to...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Hicham Sid, Theresa von Heyl, Sabrina Schleibinger, Romina Klinger, Leah Heymelot Nabel, Hanna Vikkula, Rodrigo Guabiraba, Vanaique Guillory, Ryan Scicluna, Mohanned Naif Alhussien, Brigitte Böhm, Benjamin Schade, Daniel Elleder, Samantha Sives, Lonneke Vervelde, Sascha Trapp, Benjamin Schusser
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	avian influenza virus RIG-I RNF135 transgenic chicken duck
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1680791/full