CD19+CD24hiCD38hi B Cells Are Expanded in Juvenile Dermatomyositis and Exhibit a Pro-Inflammatory Phenotype After Activation Through Toll-Like Receptor 7 and Interferon-α

Juvenile dermatomyositis (JDM) is a rare form of childhood autoimmune myositis that presents with proximal muscle weakness and skin rash. B cells are strongly implicated in the pathogenesis of the disease, but the underlying mechanisms are unknown. Therefore, the main objective of our study was to i...

Full description

Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Christopher J. M. Piper, Meredyth G. Ll. Wilkinson, Claire T. Deakin, Georg W. Otto, Stefanie Dowle, Chantal L. Duurland, Stuart Adams, Emiliano Marasco, Elizabeth C. Rosser, Anna Radziszewska, Rita Carsetti, Yiannis Ioannou, Philip L. Beales, Daniel Kelberman, David A. Isenberg, Claudia Mauri, Kiran Nistala, Lucy R. Wedderburn
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-06-01
Subjects:	immature transitional B cells B cells juvenile dermatomyositis toll-like receptor 7 interferon alpha interleukin-10
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2018.01372/full