Mutation saturation for fitness effects at human CpG sites

Whole exome sequences have now been collected for millions of humans, with the related goals of identifying pathogenic mutations in patients and establishing reference repositories of data from unaffected individuals. As a result, we are approaching an important limit, in which datasets are large en...

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Bibliographic Details

Published in:	eLife
Main Authors:	Ipsita Agarwal, Molly Przeworski
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2021-11-01
Subjects:	mutation saturation fitness effects cpg mutations interpreting protein coding variants human genetics
Online Access:	https://elifesciences.org/articles/71513