Microtubule polyglutamylation and acetylation drive microtubule dynamics critical for platelet formation

Abstract Background Upon maturation in the bone marrow, polyploid megakaryocytes elongate very long and thin cytoplasmic branches called proplatelets. Proplatelets enter the sinusoids blood vessels in which platelets are ultimately released. Microtubule dynamics, bundling, sliding, and coiling, driv...

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Bibliographic Details

Published in:	BMC Biology
Main Authors:	Juliette van Dijk, Guillaume Bompard, Julien Cau, Shinji Kunishima, Gabriel Rabeharivelo, Julio Mateos-Langerak, Chantal Cazevieille, Patricia Cavelier, Brigitte Boizet-Bonhoure, Claude Delsert, Nathalie Morin
Format:	Article
Language:	English
Published:	BMC 2018-10-01
Subjects:	Microtubules Acetylation Polyglutamylation Tubulin isotype Platelets Megakaryocytes
Online Access:	http://link.springer.com/article/10.1186/s12915-018-0584-6