Role of PDE4 Family in Cardiomyocyte Physiology and Heart Failure

Phosphodiesterase 4 (PDE4) is a key regulator of cyclic adenosine monophosphate (cAMP) signalling in cardiomyocytes, controlling contractility, calcium handling, and hypertrophic responses. PDE4 provides spatial and temporal precision to cAMP signalling, particularly under β-adrenergic stimulation,...

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Bibliographic Details
Published in:Cells
Main Authors: Ivan Sherstnev, Aleksandra Judina, Giovanni Battista Luciani, Alessandra Ghigo, Emilio Hirsch, Julia Gorelik
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Subjects:
Phosphodiesterase 4
cAMP signalling
cardiomyocyte
β-adrenergic signalling
arrhythmia
cAMP compartmentation
Online Access:https://www.mdpi.com/2073-4409/14/6/460

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https://www.mdpi.com/2073-4409/14/6/460

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