Immunoprecipitation methods impact the peptide repertoire in immunopeptidomics

IntroductionMass spectrometry-based immunopeptidomics is the only unbiased method to identify naturally presented HLA ligands, which is an indispensable prerequisite for characterizing novel tumor antigens for immunotherapeutic approaches. In recent years, improvements based on devices and methodolo...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Marcel Wacker, Jens Bauer, Laura Wessling, Marissa Dubbelaar, Annika Nelde, Hans-Georg Rammensee, Juliane S. Walz
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-07-01
Subjects:	immunotherapies HLA peptides mass spectrometry immunopeptidomics immunoprecipitation hydrophobicity
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1219720/full