The lysosomotropic drug LeuLeu-OMe induces lysosome disruption and autophagy-independent cell death in Trypanosoma brucei

Background: Trypanosoma brucei is a blood-borne, protozoan parasite that causes African sleeping sickness in humans and nagana in animals. The current chemotherapy relies on only a handful of drugs that display undesirable toxicity, poor efficacy and drug-resistance. In this study, we explored t...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Microbial Cell
المؤلفون الرئيسيون: Hazel Xinyu Koh, Htay Mon Aye, Kevin S. W. Tan, Cynthia Y. He
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Shared Science Publishers OG 2015-07-01
الموضوعات:
Trypanosoma brucei
LeuLeu-OMe
lysosome
lysosomotropic
necrosis
autophagy
الوصول للمادة أونلاين:http://microbialcell.com/researcharticles/the-lysosomotropic-drug-leuleu-ome-induces-lysosome-disruption-and-autophagy-independent-cell-death-in-trypanosoma-brucei/

الانترنت

http://microbialcell.com/researcharticles/the-lysosomotropic-drug-leuleu-ome-induces-lysosome-disruption-and-autophagy-independent-cell-death-in-trypanosoma-brucei/

مواد مشابهة