In situ sustained release of icariin from injectable thermosensitive PLGA-PEG-PLGA hydrogels combined with core decompression for steroid-induced osteonecrosis of femoral head

BackgroundIcariin (ICA) has showed the beneficial effects on preventing the occurrence of steroid-induced osteonecrosis of the femoral head (SONFH) through enhancing bone formation and remodeling. In addition, the glucocorticoid-induced inhibition of cell proliferation and apoptosis are closely rela...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Yingxing Xu, Kaige Xu, Zehua Wang, Xinyu Tang, Yaping Jiang, Tao Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	icariin PLGA-PEG-PLGA hydrogels local sustained-release drug delivery system osteonecrosis of femoral head bone marrow mesenchymal stem cells
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1643316/full