Biologically informed deep learning for explainable epigenetic clocks
Abstract Ageing is often characterised by progressive accumulation of damage, and it is one of the most important risk factors for chronic disease development. Epigenetic mechanisms including DNA methylation could functionally contribute to organismal aging, however the key functions and biological...
| Published in: | Scientific Reports |
|---|---|
| Main Authors: | Aurel Prosz, Orsolya Pipek, Judit Börcsök, Gergely Palla, Zoltan Szallasi, Sandor Spisak, István Csabai |
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-01-01
|
| Online Access: | https://doi.org/10.1038/s41598-023-50495-5 |
Similar Items
Polymerase theta expression is correlated with proliferative capacity but not with DNA repair deficiency status in solid tumors
by: Zsofia Sztupinszki, et al.
Published: (2025-06-01)
by: Zsofia Sztupinszki, et al.
Published: (2025-06-01)
Are tumor-associated carbohydrates the missing link between the gut microbiome and response to immune checkpoint inhibitor treatment in cancer?
by: Zoltan Szallasi, et al.
Published: (2024-12-01)
by: Zoltan Szallasi, et al.
Published: (2024-12-01)
A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures
by: Miklos Diossy, et al.
Published: (2021-06-01)
by: Miklos Diossy, et al.
Published: (2021-06-01)
Author Correction: Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting
by: Aurel Prosz, et al.
Published: (2024-05-01)
by: Aurel Prosz, et al.
Published: (2024-05-01)
Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting
by: Aurel Prosz, et al.
Published: (2024-04-01)
by: Aurel Prosz, et al.
Published: (2024-04-01)
Nucleotide excision repair deficiency is a targetable therapeutic vulnerability in clear cell renal cell carcinoma
by: Aurel Prosz, et al.
Published: (2023-11-01)
by: Aurel Prosz, et al.
Published: (2023-11-01)
Claudin expression in pulmonary adenoid cystic carcinoma and mucoepidermoid carcinoma
by: Marton Gyulai, et al.
Published: (2023-08-01)
by: Marton Gyulai, et al.
Published: (2023-08-01)
Epigenetic events influencing the biological clock: Panacea for neurodegeneration
by: Indrani Paramasivan Latha Laxmi, et al.
Published: (2024-10-01)
by: Indrani Paramasivan Latha Laxmi, et al.
Published: (2024-10-01)
A Targeted Epigenetic Clock for the Prediction of Biological Age
by: Noémie Gensous, et al.
Published: (2022-12-01)
by: Noémie Gensous, et al.
Published: (2022-12-01)
Epigenetic Clock Explains White Matter Hyperintensity Burden Irrespective of Chronological Age
by: Joan Jiménez-Balado, et al.
Published: (2022-12-01)
by: Joan Jiménez-Balado, et al.
Published: (2022-12-01)
Epigenetic Clocks and the Biology of Aging: Integrating Molecular Markers with Functional Trajectories
by: Arvind Mathur
Published: (2025-04-01)
by: Arvind Mathur
Published: (2025-04-01)
Mobile Antimicrobial Resistance Genes in Probiotics
by: Adrienn Gréta Tóth, et al.
Published: (2021-10-01)
by: Adrienn Gréta Tóth, et al.
Published: (2021-10-01)
Epigenetic Clock: DNA Methylation in Aging
by: Shuang Jiang, et al.
Published: (2020-01-01)
by: Shuang Jiang, et al.
Published: (2020-01-01)
An epigenetic clock for human skeletal muscle
by: Sarah Voisin, et al.
Published: (2020-08-01)
by: Sarah Voisin, et al.
Published: (2020-08-01)
Complete genes may pass from food to human blood.
by: Sándor Spisák, et al.
Published: (2013-01-01)
by: Sándor Spisák, et al.
Published: (2013-01-01)
Caregiving stress and biological aging measured by epigenetic clocks: protocol for a scoping review
by: Lena J Lee, et al.
Published: (2025-09-01)
by: Lena J Lee, et al.
Published: (2025-09-01)
Calibrating epigenetic clocks with training data error
by: Benjamin Mayne, et al.
Published: (2023-08-01)
by: Benjamin Mayne, et al.
Published: (2023-08-01)
Frequent CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression
by: Miklos Diossy, et al.
Published: (2024-09-01)
by: Miklos Diossy, et al.
Published: (2024-09-01)
Is the concept of mammalian epigenetic clocks universal and applicable to invertebrates?
by: Ryszard Maleszka
Published: (2025-08-01)
by: Ryszard Maleszka
Published: (2025-08-01)
Causal effects of cardiovascular health on five epigenetic clocks
by: Hsien-Liang Sung, et al.
Published: (2024-09-01)
by: Hsien-Liang Sung, et al.
Published: (2024-09-01)
Where are we in the implementation of tissue-specific epigenetic clocks?
by: Claudia Sala, et al.
Published: (2024-03-01)
by: Claudia Sala, et al.
Published: (2024-03-01)
Evaluation of pediatric epigenetic clocks across multiple tissues
by: Fang Fang, et al.
Published: (2023-09-01)
by: Fang Fang, et al.
Published: (2023-09-01)
The ticking of the epigenetic clock: antipsychotic drugs in old age
by: Adonis Sfera, et al.
Published: (2016-08-01)
by: Adonis Sfera, et al.
Published: (2016-08-01)
Prenatal cocaine exposure and its influence on pediatric epigenetic clocks and epigenetic scores in humans
by: Thiago Wendt Viola, et al.
Published: (2024-01-01)
by: Thiago Wendt Viola, et al.
Published: (2024-01-01)
ADP-ribosylome analysis reveals homogeneous DNA-damage-induced serine ADP-ribosylation across wild-type and BRCA-mutant breast cancer cell lines
by: Holda Awah Anagho, et al.
Published: (2024-08-01)
by: Holda Awah Anagho, et al.
Published: (2024-08-01)
ADP-ribosylome analysis reveals homogeneous DNA-damage-induced serine ADP-ribosylation across wild-type and BRCA-mutant breast cancer cell lines
by: Holda Awah Anagho, et al.
Published: (2024-07-01)
by: Holda Awah Anagho, et al.
Published: (2024-07-01)
Histopathology and proteomics are synergistic for high-grade serous ovarian cancer platinum response prediction
by: Oz Kilim, et al.
Published: (2025-01-01)
by: Oz Kilim, et al.
Published: (2025-01-01)
Notes on the continental malacofauna of Rhodes, with two new species for the fauna of the island
by: Barna Páll-Gergely, et al.
Published: (2008-09-01)
by: Barna Páll-Gergely, et al.
Published: (2008-09-01)
Physiological links of circadian clock and biological clock of aging
by: Fang Liu, et al.
Published: (2017-01-01)
by: Fang Liu, et al.
Published: (2017-01-01)
Epigenetic age and fertility timeline: testing an epigenetic clock to forecast in vitro fertilization success rate
by: Davide Marinello, et al.
Published: (2025-07-01)
by: Davide Marinello, et al.
Published: (2025-07-01)
Modification of Hardwood Veneers by Heat Treatment for Enhanced Colors
by: Sándor Fehér, et al.
Published: (2014-04-01)
by: Sándor Fehér, et al.
Published: (2014-04-01)
Assessing the utility of epigenetic clocks for health prediction in South Korean
by: Dong Jun Kim, et al.
Published: (2024-12-01)
by: Dong Jun Kim, et al.
Published: (2024-12-01)
Development of an epigenetic clock resistant to changes in immune cell composition
by: Alan Tomusiak, et al.
Published: (2024-08-01)
by: Alan Tomusiak, et al.
Published: (2024-08-01)
Transfer Elastic Net for Developing Epigenetic Clocks for the Japanese Population
by: Yui Tomo, et al.
Published: (2024-08-01)
by: Yui Tomo, et al.
Published: (2024-08-01)
Novel Epigenetic Clock Biomarkers of Age-Related Macular Degeneration
by: Saurav Mallik, et al.
Published: (2022-06-01)
by: Saurav Mallik, et al.
Published: (2022-06-01)
The epigenetic clock and pubertal, neuroendocrine, psychiatric, and cognitive outcomes in adolescents
by: Anna Suarez, et al.
Published: (2018-07-01)
by: Anna Suarez, et al.
Published: (2018-07-01)
Desynchronization of Circadian Clocks in Cancer: A Metabolic and Epigenetic Connection
by: Kiran Padmanabhan, et al.
Published: (2017-06-01)
by: Kiran Padmanabhan, et al.
Published: (2017-06-01)
A new cognitive clock matching phenotypic and epigenetic ages
by: M. I. Krivonosov, et al.
Published: (2022-09-01)
by: M. I. Krivonosov, et al.
Published: (2022-09-01)
A biallelic multiple nucleotide length polymorphism explains functional causality at 5p15.33 prostate cancer risk locus
by: Sandor Spisak, et al.
Published: (2023-08-01)
by: Sandor Spisak, et al.
Published: (2023-08-01)
Author Correction: A biallelic multiple nucleotide length polymorphism explains functional causality at 5p15.33 prostate cancer risk locus
by: Sandor Spisak, et al.
Published: (2023-10-01)
by: Sandor Spisak, et al.
Published: (2023-10-01)
Similar Items
-
Polymerase theta expression is correlated with proliferative capacity but not with DNA repair deficiency status in solid tumors
by: Zsofia Sztupinszki, et al.
Published: (2025-06-01) -
Are tumor-associated carbohydrates the missing link between the gut microbiome and response to immune checkpoint inhibitor treatment in cancer?
by: Zoltan Szallasi, et al.
Published: (2024-12-01) -
A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures
by: Miklos Diossy, et al.
Published: (2021-06-01) -
Author Correction: Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting
by: Aurel Prosz, et al.
Published: (2024-05-01) -
Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting
by: Aurel Prosz, et al.
Published: (2024-04-01)
