Effects of Mediterranean diet, exercise, and their combination on body composition and liver outcomes in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis of randomized controlled trials

Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of liver-related morbidity and mortality. Lifestyle interventions like the Mediterranean diet (MD) and exercise are recommended for management, but the most effective lifestyle approach remains un...

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Published in:	BMC Medicine
Main Authors:	Vicente Artola Arita, Manuel Castro Cabezas, Juliana Alexandra Hernández Vargas, Silvia Juliana Trujillo-Cáceres, Nathalie Mendez Pernicone, Lara Anne Bridge, Hamidreza Raeisi-Dehkordi, Carmen A. W. Dietvorst, Ruben Dekker, Julieth Pilar Uriza-Pinzón, Mohamed Tawfik, Kirsten A. Berk, Jo Massoels, Stan Driessen, Maarten E. Tushuizen, Adriaan G. Holleboom, Diederick E. Grobbee, Oscar H. Franco, Sara Beigrezaei, GRIPonMASH Consortium
Format:	Article
Language:	English
Published:	BMC 2025-08-01
Subjects:	Lifestyle Metabolic dysfunction-associated steatotic liver disease Non-alcoholic fatty liver disease Metabolic dysfunction-associated steatohepatitis Mediterranean diet Exercise
Online Access:	https://doi.org/10.1186/s12916-025-04320-7