CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events.

Juvenile Batten disease (juvenile neuronal ceroid lipofuscinosis, JNCL) is a devastating neurodegenerative disease caused by mutations in CLN3, a protein of undefined function. Cell lines derived from patients or mice with CLN3 deficiency have impairments in actin-regulated processes such as endocyt...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Mark L Schultz, Luis Tecedor, Colleen S Stein, Mark A Stamnes, Beverly L Davidson
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2014-01-01
Online Access:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096647&type=printable