Identification and precision therapy for three maturity-onset diabetes of the young (MODY) families caused by mutations in the HNF4A gene

BackgroundHeterozygous pathogenic variants in HNF4A gene cause maturity-onset diabetes of the young type 1 (MODY1). The mutation carriers for MODY1 have been reported to be relatively rare, in contrast to the most frequently reported forms of MODY2 and MODY3.MethodsWhole exome sequencing (WES) and S...

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Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Authors:	Juan Zhang, Yanyan Jiang, Jianhua Li, Haiyin Zou, Li Yin, Yang Yang, Lei Yang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-08-01
Subjects:	maturity-onset diabetes of the young HNF4A gene mutation precision therapy whole exome sequencing
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2023.1237553/full