FBXW7β loss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth

Abstract Continuous de novo fatty acid synthesis is required for the biosynthetic demands of tumor. FBXW7 is a highly mutated gene in CRC, but its biological functions in cancer are not fully characterized. Here, we report that FBXW7β, a FBXW7 isoform located in the cytoplasm and frequently mutated...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Signal Transduction and Targeted Therapy
المؤلفون الرئيسيون:	Wenxia Wei, Baifu Qin, Weijie Wen, Boyu Zhang, Haidan Luo, Yuzhi Wang, Hui Xu, Xiaoshan Xie, Sicheng Liu, Xin Jiang, Mengan Wang, Qin Tang, Jiayu Zhang, Runxiang Yang, Zongmin Fan, Haiwen Lyu, Junzhong Lin, Kai Li, Mong-Hong Lee
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Nature Publishing Group 2023-05-01
الوصول للمادة أونلاين:	https://doi.org/10.1038/s41392-023-01405-8