The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis, down-regulates the CXCR4 chemokine receptor and impairs migration of chronic lymphocytic leukemia cells

Background Chronic lymphocytic leukemia is a neoplastic disorder that arises largely as a result of defective apoptosis leading to chemoresistance. Stromal cell-derived factor-1 and its receptor, CXCR4, have been shown to play an important role in chronic lymphocytic leukemia cell trafficking and su...

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Bibliographic Details

Published in:	Haematologica
Main Authors:	Basile Stamatopoulos, Nathalie Meuleman, Cécile De Bruyn, Alain Delforge, Dominique Bron, Laurence Lagneaux
Format:	Article
Language:	English
Published:	Ferrata Storti Foundation 2010-07-01
Online Access:	https://haematologica.org/article/view/5656