Antidepressant-like Effects of BDNF and NGF Individual Loop Dipeptide Mimetics Depend on the Signal Transmission Patterns Associated with Trk

Neurotrophins are considered as an attractive target for the development of antidepressants with a novel mechanism of action. Previously, the dimeric dipeptide mimetics of individual loops of nerve growth factor, NGF (GK-6, loop 1; GK-2, loop 4) and brain-derived neurotrophic factor, BDNF (GSB-214,...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Armen G. Mezhlumyan, Anna V. Tallerova, Polina Y. Povarnina, Aleksey V. Tarasiuk, Nellya M. Sazonova, Tatiana A. Gudasheva, Sergey B. Seredenin
Format:	Article
Language:	English
Published:	MDPI AG 2022-02-01
Subjects:	NGF BDNF low-molecular weight mimetic MAPK/ERK PI3K/AKT PLC
Online Access:	https://www.mdpi.com/1424-8247/15/3/284