p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways

Classically, p53 tumor suppressor acts in transcription, apoptosis, and cell cycle arrest. Yet, replication-mediated genomic instability is integral to oncogenesis, and p53 mutations promote tumor progression and drug-resistance. By delineating human and murine separation-of-function p53 alleles, we...

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發表在:	eLife
Main Authors:	Sunetra Roy, Karl-Heinz Tomaszowski, Jessica W Luzwick, Soyoung Park, Jun Li, Maureen Murphy, Katharina Schlacher
格式:	Article
語言:	英语
出版:	eLife Sciences Publications Ltd 2018-01-01
主題:	p53 genome instability replication fork restart MRE11 BRCA2 replication protection
在線閱讀:	https://elifesciences.org/articles/31723