Excess glucose alone depress young mesenchymal stromal/stem cell osteogenesis and mitochondria activity within hours/days via NAD+/SIRT1 axis

Abstract Background The impact of global overconsumption of simple sugars on bone health, which peaks in adolescence/early adulthood and correlates with osteoporosis (OP) and fracture risk decades, is unclear. Mesenchymal stromal/stem cells (MSCs) are the progenitors of osteoblasts/bone-forming cell...

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Bibliographic Details
Published in:Journal of Biomedical Science
Main Authors: B. Linju Yen, Li-Tzu Wang, Hsiu-Huang Wang, Chin-Pao Hung, Pei-Ju Hsu, Chia-Chi Chang, Chien-Yu Liao, Huey-Kang Sytwu, Men-Luh Yen
Format: Article
Language:English
Published: BMC 2024-05-01
Subjects:
Human mesenchymal stromal/stem cells (MSCs)
Osteogenesis
Adipogenesis
Mitochondria
High glucose
Mouse model
Online Access:https://doi.org/10.1186/s12929-024-01039-0

Internet

https://doi.org/10.1186/s12929-024-01039-0

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