The Complexity of Bariatric Patient’s Pharmacotherapy: Sildenafil Biopharmaceutics and Pharmacokinetics before vs. after Gastric Sleeve/Bypass

Postbariatric altered gastrointestinal (GI) anatomy/physiology may significantly harm oral drug absorption and overall bioavailability. In this work, sildenafil, the first phosphodiesterase-5 (PDE5) inhibitor, was investigated for impaired postbariatric solubility/dissolution and absorption; this re...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Daniel Porat, Oleg Dukhno, Sandra Cvijić, Arik Dahan
Format:	Article
Language:	English
Published:	MDPI AG 2023-12-01
Subjects:	bariatric surgery oral absorption gastric pH ex vivo solubility postbariatric dissolution delayed onset
Online Access:	https://www.mdpi.com/1999-4923/15/12/2795