Dysregulating PHO Signaling via the CDK Machinery Differentially Impacts Energy Metabolism, Calcineurin Signaling, and Virulence in Cryptococcus neoformans

ABSTRACT Fungal pathogens uniquely regulate phosphate homeostasis via the cyclin-dependent kinase (CDK) signaling machinery of the phosphate acquisition (PHO) pathway (Pho85 kinase-Pho80 cyclin-CDK inhibitor Pho81), providing drug-targeting opportunities. Here, we investigate the impact of a PHO pat...

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Bibliographic Details

Published in:	mBio
Main Authors:	Bethany Grace Bowring, Pooja Sethiya, Desmarini Desmarini, Sophie Lev, Lisa Tran Le, Yong-Sun Bahn, Seung-Heon Lee, Akio Toh-e, Nicholas Proschogo, Tom Savage, Julianne Teresa Djordjevic
Format:	Article
Language:	English
Published:	American Society for Microbiology 2023-04-01
Subjects:	phosphate homeostasis PHO pathway Pho80 Pho81 polyphosphate polyP
Online Access:	https://journals.asm.org/doi/10.1128/mbio.03551-22