Hepatocellular heme oxygenase 1 deficiency does not affect inflammatory hepcidin regulation in mice.
Hepcidin is an iron regulatory peptide hormone that is secreted from hepatocytes and inhibits iron efflux from tissues to plasma. Under inflammatory conditions, hepcidin is transcriptionally induced by IL-6/STAT3 signaling and promotes hypoferremia, an innate immune response to infection. If this pa...
| Published in: | PLoS ONE |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2019-01-01
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| Online Access: | https://doi.org/10.1371/journal.pone.0219835 |