Defective Localization With Impaired Tumor Cytotoxicity Contributes to the Immune Escape of NK Cells in Pancreatic Cancer Patients

Tumor-infiltrating lymphocytes (TILs), found in patients with advanced pancreatic ductal adenocarcinoma (PDAC), are shown to correlate with overall survival (OS) rate. Although majority of TILs consist of CD8+/CD4+ T cells, the presence of NK cells and their role in the pathogenesis of PDAC remains...

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Bibliographic Details
Published in:Frontiers in Immunology
Main Authors: Seon Ah Lim, Jungwon Kim, Seunghyun Jeon, Min Hwa Shin, Joonha Kwon, Tae-Jin Kim, Kyungtaek Im, Youngmin Han, Wooil Kwon, Sun-Whe Kim, Cassian Yee, Seong-Jin Kim, Jin-Young Jang, Kyung-Mi Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Subjects:
pancreatic cancer
cancer immunobiology
cellular immunology
immunotherapy
chemokines
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00496/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00496/full

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