Development of a Humanized VHH Based Recombinant Antibody Targeting Claudin 18.2 Positive Cancers

Claudin 18.2 (CLDN18.2), a tight junction (TJ) family protein controlling molecule exchange between cells, is frequently over-expressed in gastric cancer, pancreatic adenocarcinomas and in a fraction of non–small cell lung cancer cases. The tumor properties indicate that CLDN18.2 could be an attract...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Weixiang Zhong, Yimin Lu, Zhe Ma, Yinjun He, Yongfeng Ding, Gaofeng Yao, Zhenxing Zhou, Jiali Dong, Yongliang Fang, Weiqin Jiang, Weilin Wang, Yanshan Huang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Subjects:	Claudin 18.2 VHH gastric cancer pancreatic cancer ADCC CDC
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.885424/full