Oxoglutarate Carrier Inhibition Reduced Melanoma Growth and Invasion by Reducing ATP Production

Recent findings indicate that (a) mitochondria in proliferating cancer cells are functional, (b) cancer cells use more oxygen than normal cells for oxidative phosphorylation, and (c) cancer cells critically rely on cytosolic NADH transported into mitochondria via the malate-aspartate shuttle (MAS) f...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Jae-Seon Lee, Jiwon Choi, Seon-Hyeong Lee, Joon Hee Kang, Ji Sun Ha, Hee Yeon Kim, Hyonchol Jang, Jong In Yook, Soo-Youl Kim
Format:	Article
Language:	English
Published:	MDPI AG 2020-11-01
Subjects:	oxoglutarate carrier malate-aspartate shuttle cancer metabolism ATP production
Online Access:	https://www.mdpi.com/1999-4923/12/11/1128