Dual targeting of histone deacetylases and MYC as potential treatment strategy for H3-K27M pediatric gliomas

Diffuse midline gliomas (DMGs) are aggressive and fatal pediatric tumors of the central nervous system that are highly resistant to treatments. Lysine to methionine substitution of residue 27 on histone H3 (H3-K27M) is a driver mutation in DMGs, reshaping the epigenetic landscape of these cells to p...

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الحاوية / القاعدة:	eLife
المؤلفون الرئيسيون:	Danielle Algranati, Roni Oren, Bareket Dassa, Liat Fellus-Alyagor, Alexander Plotnikov, Haim Barr, Alon Harmelin, Nir London, Guy Ron, Noa Furth, Efrat Shema
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	eLife Sciences Publications Ltd 2024-08-01
الموضوعات:	DMG epigenetics oncogene
الوصول للمادة أونلاين:	https://elifesciences.org/articles/96257