Whole body and hematopoietic cell-specific deletion of G-protein coupled receptor 65 (GPR65) improves insulin sensitivity in diet-induced obese mice

Objective: Acidic extracellular microenvironments, resulting from enhanced glycolysis and lactic acid secretion by immune cells, along with metabolic acidosis may interfere with the insulin signaling pathway and contribute to the development of insulin resistance. In the present study, we investigat...

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Bibliographic Details

Published in:	Molecular Metabolism
Main Authors:	Yingjiang Zhou, EunJu Bae, Simon S. Hoffman, Da Young Oh, Gordon I. Smith, Samuel Klein, Saswata Talukdar
Format:	Article
Language:	English
Published:	Elsevier 2025-07-01
Subjects:	GPR65 Inflammation Insulin resistance Obesity Hyperinsulinemic-euglycemic clamp
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212877825000766