Effects of CRISPR-Cas9-mediated CEP55 gene knockout on immune evasion mechanisms of liver cancer cells

Abstract This study investigates the role of centrosomal protein CEP55 in immune evasion by liver cancer cells and evaluates the effects of its knockout using CRISPR-Cas9 technology. CEP55-knockout models were established in human hepatocellular carcinoma cell lines Huh7 and HepG2, and alterations i...

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Bibliographic Details
Published in:Scientific Reports
Main Authors: Chenwei Hu, Wei Zhang, Hailong Ge, Yu Wang, Chen Chao, Xingsong Shi, Xiaobing Zhou, Chen Wang
Format: Article
Language:English
Published: Nature Portfolio 2026-04-01
Subjects:
CEP55
CRISPR-Cas9
PD-L1
Liver cancer
Immune escape
Online Access:https://doi.org/10.1038/s41598-026-46882-3

Internet

https://doi.org/10.1038/s41598-026-46882-3

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