TRPML1 gating modulation by allosteric mutations and lipids
Transient Receptor Potential Mucolipin 1 (TRPML1) is a lysosomal cation channel whose loss-of-function mutations directly cause the lysosomal storage disorder mucolipidosis type IV (MLIV). TRPML1 can be allosterically regulated by various ligands including natural lipids and small synthetic molecule...
| 出版年: | eLife |
|---|---|
| 主要な著者: | , , , |
| フォーマット: | 論文 |
| 言語: | 英語 |
| 出版事項: |
eLife Sciences Publications Ltd
2024-10-01
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| 主題: | |
| オンライン･アクセス: | https://elifesciences.org/articles/100987 |