Gonadal androgens are associated with decreased type I interferon production by plasmacytoid dendritic cells and increased IgG titres to BNT162b2 following co-vaccination with live attenuated influenza vaccine in adolescents

mRNA vaccine technologies introduced following the SARS-CoV-2 pandemic have highlighted the need to better understand the interaction of adjuvants and the early innate immune response. Type I interferon (IFN-I) is an integral part of this early innate response that primes several components of the a...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Oliver L. Sampson, Cecilia Jay, Emily Adland, Anna Csala, Nicholas Lim, Stella M. Ebbrecht, Lorna C. Gilligan, Angela E. Taylor, Sherley Sherafin George, Stephanie Longet, Lucy C. Jones, Ellie Barnes, John Frater, Paul Klenerman, Susie Dunachie, Miles Carrol, James Hawley, Wiebke Arlt, Andreas Groll, Philip Goulder
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-02-01
Subjects:	type I interferon plasmacytoid dendritic cell immune sex difference androgen adolescent vaccination
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1329805/full