Monoclonal antibody targeting mu-opioid receptor attenuates morphine tolerance via enhancing morphine-induced receptor endocytosis

Morphine is a frequently used analgesic that activates the mu-opioid receptor (MOR), which has prominent side effects of tolerance. Although the inefficiency of morphine in inducing the endocytosis of MOR underlies the development of morphine tolerance, currently, there is no effective therapy to tr...

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發表在:	Journal of Pharmaceutical Analysis
Main Authors:	Jia-Jia Zhang, Chang-Geng Song, Miao Wang, Gai-Qin Zhang, Bin Wang, Xi Chen, Peng Lin, Yu-Meng Zhu, Zhi-Chuan Sun, Ya-Zhou Wang, Jian-Li Jiang, Ling Li, Xiang-Min Yang, Zhi-Nan Chen
格式:	Article
語言:	英语
出版:	Elsevier 2023-10-01
主題:	Morphine tolerance Mu-opioid receptor Endocytosis Monoclonal antibody Physical dependence
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2095177923001211