Unveiling the impact of CDK8 on tumor progression: mechanisms and therapeutic strategies

CDK8 is an important member of the cyclin-dependent kinase family associated with transcription and acts as a key “molecular switch” in the Mediator complex. CDK8 regulates gene expression by phosphorylating transcription factors and can control the transcription process through Mediator complex. Pr...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Xiaomin Yin, Zhilong He, Kun Chen, Kai Ouyang, Changxuan Yang, Jianjun Li, Hailin Tang, Manbo Cai
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-03-01
Subjects:	tumorigenesis CDK8 immune cell cycle invasion energy metabolism
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1386929/full