The calcium channel modulator 2-APB hydrolyzes in physiological buffers and acts as an effective radical scavenger and inhibitor of the NADPH oxidase 2

2-aminoethoxydiphenyl borate (2-APB) is commonly used as a tool to modulate calcium signaling in physiological studies. 2-APB has a complex pharmacology and acts as activator or inhibitor of a variety of Ca2+ channels and transporters. While unspecific, 2-APB is one of the most-used agents to modula...

Full description

Bibliographic Details

Published in:	Redox Biology
Main Authors:	Ewa Jasmin Slowik, Katerina Stankoska, Nhat Nguyen Bui, Bastian Pasieka, David Conrad, Josef Zapp, Markus Hoth, Ivan Bogeski, Reinhard Kappl
Format:	Article
Language:	English
Published:	Elsevier 2023-05-01
Subjects:	2-APB Ca-signaling Reactive oxygen species (ROS) Hydrolysis Degradation NOX inhibition
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231723000551