NcROP2 deletion reduces Neospora caninum virulence by altering parasite stage differentiation and hijacking host immune response

IntroductionNeospora caninum is an apicomplexan parasite responsible for bovine neosporosis, a major cause of abortion in cattle worldwide. N. caninum rhoptry protein 2 (NcROP2) has been identified as an essential factor in host cell invasion and parasitophorous vacuole formation, making it a potent...

Full description

Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Rafael Amieva, Montserrat Coronado, Jessica Powell, David Arranz-Solís, Musa A. Hassan, Esther Collantes-Fernández, Luis Miguel Ortega-Mora, Pilar Horcajo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Subjects:	Neospora caninum virulence factor NcROP2 CRISPR/Cas9 BALB/c bovine macrophages
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1617570/full