Multi‐omics profiling identifies TNFRSF18 as a novel marker of exhausted CD8⁺ T cells and reveals tumour‐immune dynamics in colorectal cancer

Abstract Background Colorectal cancer (CRC) ranks among the most prevalent malignant tumours of the digestive system globally and is associated with unfavourable survival outcomes. The exhaustion of CD8⁺ T cells serves a crucial role in facilitating tumour immune escape. Yet, the dynamic evolution o...

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Bibliographic Details

Published in:	Clinical and Translational Medicine
Main Authors:	Tengfei Jia, Yingxi Guo, Xin meng Cheng, Zeyang Zhou, Xiaojiang Xu, Hebin Liu, Xiaodong Yang
Format:	Article
Language:	English
Published:	Wiley 2025-08-01
Subjects:	colorectal cancer singlecell RNA sequencing spatial transcriptomics T cell exhaustion TNFRSF18 (GITR) TNM stage
Online Access:	https://doi.org/10.1002/ctm2.70425