Choline metabolism reprogramming mediates an immunosuppressive microenvironment in non-small cell lung cancer (NSCLC) by promoting tumor-associated macrophage functional polarization and endothelial cell proliferation

Abstract Introduction Lung cancer is a prevalent malignancy globally, and immunotherapy has revolutionized its treatment. However, resistance to immunotherapy remains a challenge. Abnormal cholinesterase (ChE) activity and choline metabolism are associated with tumor oncogenesis, progression, and po...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Bijing Xiao, Guanjun Li, Haimiti Gulizeba, Hong Liu, Xiaoxian Sima, Ting Zhou, Yan Huang
Format:	Article
Language:	English
Published:	BMC 2024-05-01
Subjects:	Non-small cell lung cancer Cholinesterase Choline metabolism Immunotherapy response Metabolic reprogramming Immune microenvironment
Online Access:	https://doi.org/10.1186/s12967-024-05242-3