Suppression of TREX1 deficiency-induced cellular senescence and interferonopathies by inhibition of DNA damage response

Summary: TREX1 encodes a major DNA exonuclease and mutations of this gene are associated with type I interferonopathies in human. Mice with Trex1 deletion or mutation have shortened life spans accompanied by a senescence-associated secretory phenotype. However, the contribution of cellular senescenc...

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Bibliographic Details

Published in:	iScience
Main Authors:	Hekang Du, Nanyang Xiao, Sitong Zhang, Xueyuan Zhou, Yangfan Zhang, Zengzeng Lu, Yuqian Fu, Miaohui Huang, Shan Xu, Qi Chen
Format:	Article
Language:	English
Published:	Elsevier 2023-07-01
Subjects:	Disease Molecular biology Model organism
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004223011677