The polyphenol metabolite urolithin A suppresses myostatin expression and augments glucose uptake in human skeletal muscle cells

Abstract Purpose Polyphenolic plant extracts have demonstrated anti-inflammatory and anti-catabolic effects in vitro, however their meaningful translation into humans remains elusive. Urolithin A (UA), a gut-derived metabolite of ellagitannins, has shown promise for improving muscle function and met...

Full description

Bibliographic Details

Published in:	Nutrition & Metabolism
Main Authors:	Andrew Wilhelmsen, Leonidas G Karagounis, Andrew J. Bennett, Davide D’Amico, Andréane M. Fouassier, Simon W. Jones, Kostas Tsintzas
Format:	Article
Language:	English
Published:	BMC 2025-02-01
Subjects:	Insulin sensitivity Anabolic sensitivity Skeletal muscle Primary human myotubes Urolithin A
Online Access:	https://doi.org/10.1186/s12986-025-00909-0