Context Matters: NOTCH Signatures and Pathway in Cancer Progression and Metastasis

The Notch signaling pathway is a critical player in embryogenesis but also plays various roles in tumorigenesis, with both tumor suppressor and oncogenic activities. Mutations, deletions, amplifications, or over-expression of Notch receptors, ligands, and a growing list of downstream Notch-activated...

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Bibliographic Details

Published in:	Cells
Main Authors:	Julia O. Misiorek, Alicja Przybyszewska-Podstawka, Joanna Kałafut, Beata Paziewska, Katarzyna Rolle, Adolfo Rivero-Müller, Matthias Nees
Format:	Article
Language:	English
Published:	MDPI AG 2021-01-01
Subjects:	Notch signaling pathway tumor progression oncogenic mutations tumor suppressor gene gain and loss of function mutations (GOF and LOF) epithelial-mesenchymal transition (EMT)
Online Access:	https://www.mdpi.com/2073-4409/10/1/94