Therapeutic inhibition of miR-155 attenuates liver fibrosis via STAT3 signaling

Most chronic liver diseases progress to liver fibrosis, which, when left untreated, can lead to cirrhosis and hepatocellular carcinoma. MicroRNA (miRNA)-targeted therapeutics have become attractive approaches to treat diseases. In this study, we investigated the therapeutic effect of miR-155 inhibit...

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Bibliographic Details

Published in:	Molecular Therapy: Nucleic Acids
Main Authors:	Shashi Bala, Yuan Zhuang, Prashanth Thevkar Nagesh, Donna Catalano, Adam Zivny, Yanbo Wang, Jun Xie, Guangping Gao, Gyongyi Szabo
Format:	Article
Language:	English
Published:	Elsevier 2023-09-01
Subjects:	MT: Non-coding RNAs anti-miR-155 tough decoy SMAD2/3 STAT3 CCl4 BDL
Online Access:	http://www.sciencedirect.com/science/article/pii/S2162253123001853