Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice

Genetic and molecular approaches have been critical for elucidating the mechanism of the mammalian circadian clock. Here, we demonstrate that the ClockΔ19 mutant behavioral phenotype is significantly modified by mouse strain genetic background. We map a suppressor of the ClockΔ19 mutation to a ∼900...

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Bibliographic Details

Published in:	eLife
Main Authors:	Kazuhiro Shimomura, Vivek Kumar, Nobuya Koike, Tae-Kyung Kim, Jason Chong, Ethan D Buhr, Andrew R Whiteley, Sharon S Low, Chiaki Omura, Deborah Fenner, Joseph R Owens, Marc Richards, Seung-Hee Yoo, Hee-Kyung Hong, Martha H Vitaterna, Joseph Bass, Mathew T Pletcher, Tim Wiltshire, John Hogenesch, Phillip L Lowrey, Joseph S Takahashi
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2013-04-01
Subjects:	Clock gene USF1 genetic modifier circadian rhythm mouse genetic ChIP-Seq
Online Access:	https://elifesciences.org/articles/00426