Stimulation of the Hydroxycarboxylic Acid Receptor 2 With the Ketone Body 3‐Hydroxybutyrate and Niacin in Patients With Chronic Heart Failure: Hemodynamic and Metabolic Effects

Background The ketone body 3‐hydroxybutyrate (3‐OHB) increases cardiac output (CO) in patients with heart failure through unknown mechanisms. 3‐OHB activates the hydroxycarboxylic acid receptor 2 (HCA2), which increases prostaglandins and suppresses circulating free fatty acids. We investigated whet...

Full description

Bibliographic Details

Published in:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Main Authors:	Nigopan Gopalasingam, Kristian Hylleberg Christensen, Kristoffer Berg Hansen, Roni Nielsen, Mogens Johannsen, Lars Christian Gormsen, Ebbe Boedtkjer, Rikke Nørregaard, Niels Møller, Henrik Wiggers
Format:	Article
Language:	English
Published:	Wiley 2023-06-01
Subjects:	HCA2 receptor heart failure hemodynamics ketone body metabolic
Online Access:	https://www.ahajournals.org/doi/10.1161/JAHA.123.029849