The spike S2 substitution, P804L, drives the adaptation of BANAL-20–236 to a broad range of Rhinolophus bat ACE2

Understanding how bat coronaviruses circulate in wildlife, including bats in nature, can help assess the risks of cross-species transmission of potentially pathogenic viruses to humans. However, the evolutionary molecular mechanisms that enable sarbecoviruses to utilize diverse Rhinolophus bat ACE2...

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Bibliographic Details

Published in:	Frontiers in Virology
Main Authors:	Luo Chen, Alfredo A. Hinay, Shigeru Fujita, Jumpei Ito, Hiroyuki Asakura, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Kei Sato
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	coronavirus sarbecovirus adaptation Rhinolophus bat ACE2 spillover
Online Access:	https://www.frontiersin.org/articles/10.3389/fviro.2025.1612630/full