The influence of prompt engineering on large language models for protein–protein interaction identification in biomedical literature

Abstract Identifying protein–protein interactions (PPIs) is a foundational task in biomedical natural language processing. While specialized models have been developed, the potential of general-domain large language models (LLMs) in PPI extraction, particularly for researchers without computational...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Yung-Chun Chang, Ming-Siang Huang, Yi-Hsuan Huang, Yi-Hsuan Lin
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-05-01
Subjects:	Relation extraction Protein–protein interaction Natural language processing Large language model
Online Access:	https://doi.org/10.1038/s41598-025-99290-4