The impact of serotype-specific vaccination on phylodynamic parameters of Streptococcus pneumoniae and the pneumococcal pan-genome.

In the United States, the introduction of the heptavalent pneumococcal conjugate vaccine (PCV) largely eliminated vaccine serotypes (VT); non-vaccine serotypes (NVT) subsequently increased in carriage and disease. Vaccination also disrupts the composition of the pneumococcal pangenome, which include...

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Bibliographic Details

Published in:	PLoS Pathogens
Main Authors:	Taj Azarian, Lindsay R Grant, Brian J Arnold, Laura L Hammitt, Raymond Reid, Mathuram Santosham, Robert Weatherholtz, Novalene Goklish, Claudette M Thompson, Stephen D Bentley, Katherine L O'Brien, William P Hanage, Marc Lipsitch
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2018-04-01
Online Access:	https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006966&type=printable