MAP Kinase Pathways in Brain Endothelial Cells and Crosstalk with Pericytes and Astrocytes Mediate Contrast-Induced Blood–Brain Barrier Disruption

Neurointervention with contrast media (CM) has rapidly increased, but the impact of CM extravasation and the related side effects remain controversial. This study investigated the effect of CM on blood–brain barrier (BBB) integrity. We established in vitro BBB models using primary cultures of rat BB...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Yuki Matsunaga, Shinsuke Nakagawa, Yoichi Morofuji, Shinya Dohgu, Daisuke Watanabe, Nobutaka Horie, Tsuyoshi Izumo, Masami Niwa, Fruzsina R. Walter, Ana Raquel Santa-Maria, Maria A. Deli, Takayuki Matsuo
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Subjects:	blood–brain barrier contrast media iopamidol MAP kinase pericytes astrocytes
Online Access:	https://www.mdpi.com/1999-4923/13/8/1272