Design, Synthesis, Biological Evaluation and In Silico Studies of Pyrazole-Based NH₂-Acyl Oseltamivir Analogues as Potent Neuraminidase Inhibitors

Oseltamivir represents one of the most successful neuraminidase (NA) inhibitors in the current anti-influenza therapy. The 150-cavity of NA was identified as an additional binding pocket, and novel NA inhibitors have been designed to occupy the 150-cavity based on the structure information of oselta...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Jiqing Ye, Lin Lin, Jinyi Xu, Paul Kay-sheung Chan, Xiao Yang, Cong Ma
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Subjects:	influenza virus neuraminidase inhibitor 150-cavity oseltamivir derivatives pyrazole
Online Access:	https://www.mdpi.com/1424-8247/14/4/371