Case Report: Severe HHV-6-related encephalitis following anti-CD19 CAR-T therapy with no evidence of HHV-6 reactivation in transduced CAR-T cells

We report a case of severe encephalitis caused by human herpes virus 6 (HHV-6) following CD19 chimeric antigen receptor T (CAR-T) cell therapy. Rapid expansion of circulating T-lymphocytes and high HHV-6 viral load (4,500,000 DNA copies/mL) early after CAR-T infusion suggested HHV-6 transferal from...

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Bibliographic Details

Published in:	Frontiers in Hematology
Main Authors:	Nina Marie Birk, Katrine Kielsen, Özcan Met, Eva Kannik Haastrup, Thomas M. Hulen, Cecilie Ø. Madsen, Torben Barington, Jonas Nielsen, Kristian Schønning, Søren Lykke Petersen, Marianne Ifversen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	CAR-T therapy HHV-6 encephalitis ICANS neurotoxicity
Online Access:	https://www.frontiersin.org/articles/10.3389/frhem.2025.1628552/full