Germline variants of uncertain significance, their frequency, and clinico-pathological features in a cohort of Sri Lankan patients with hereditary breast cancer

Abstract Background Next-Generation Sequencing (NGS)-based testing in cancer patients has led to increased detection of variants of uncertain significance (VUS). VUS are genetic variants whose impact on protein function is unknown. VUS pose a challenge to clinicians and patients due to uncertainty r...

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Bibliographic Details

Published in:	BMC Research Notes
Main Authors:	Kawmadi Gunawardena, Nirmala D. Sirisena, Gayani Anandagoda, Nilaksha Neththikumara, Vajira H.W. Dissanayake
Format:	Article
Language:	English
Published:	BMC 2023-06-01
Subjects:	Breast cancer cancer phenotype Germline variants Hereditary cancer VUS
Online Access:	https://doi.org/10.1186/s13104-023-06365-4