Synthesis and Cap-Dependent Endonuclease Inhibition of Baloxavir Derivatives

Baloxavir marboxil is a creative antiviral drug for influenza A and B viruses with a novel mechanism of action. In this study, three series comprising a total of 21 previously unreported target compounds were designed and synthesized. The drug-likeness of these compounds was evaluated by molecular d...

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Bibliographic Details

Published in:	Crystals
Main Authors:	Yiyun Wang, Jiaru Wang, Hui Wu, Longyao Cui, Zihui Meng, Zhibin Xu, Zhonghui Zheng, Jiarong Li
Format:	Article
Language:	English
Published:	MDPI AG 2023-06-01
Subjects:	baloxavir derivatives synthesis inhibition
Online Access:	https://www.mdpi.com/2073-4352/13/7/988